The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …

Ample data indicate that mutant p53 proteins not only lose their tumour suppressive
functions, but also gain new abilities that promote tumorigenesis. Moreover, recent studies …

Numerous studies have tested the association between TP53 mutations in ovarian cancer
and prognosis but these have been consistently confounded by limitations in study design …

In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection
against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding …

A complex disease generally results not from malfunction of individual molecules but from
dysfunction of the relevant system or network, which dynamically changes with time and …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Abstract MicroRNA-34a (miR-34a) is a transcriptional target of p53 that is down-regulated in
some cancer cell lines. We studied the expression, targets, and functional effects of miR-34a …

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is one of the most
frequently disrupted tumor suppressors in cancer. The lipid phosphatase activity of PTEN …

Ataxia telangiectasia (AT) mutated (ATM) is critical for cell cycle checkpoints and DNA
repair. Thus, specific small molecule inhibitors targeting ATM could perhaps be developed …

We recently found that microRNA-34a (miR-34a) is downregulated in human glioma tumors
as compared to normal brain, and that miR-34a levels in mutant-p53 gliomas were lower …