Heart rate variability: a diagnostic and prognostic tool in anesthesia and intensive care

AT Mazzeo, E La Monaca, R Di Leo… - Acta …, 2011 - Wiley Online Library
The autonomic nervous system (ANS) plays an important role in the human response to
various internal and external stimuli, which can modify homeostasis, and exerts a tight …

The compensatory reserve for early and accurate prediction of hemodynamic compromise: a review of the underlying physiology

VA Convertino, MD Wirt, JF Glenn, BC Lein - Shock, 2016 - journals.lww.com
Shock is deadly and unpredictable if it is not recognized and treated in early stages of
hemorrhage. Unfortunately, measurements of standard vital signs that are displayed on …

Identifying risk for massive transfusion in the relatively normotensive patient: utility of the prehospital shock index

MJ Vandromme, RL Griffin, JD Kerby… - Journal of Trauma …, 2011 - journals.lww.com
Background: In the prehospital environment, the failure of medical providers to recognize
latent physiologic derangement in patients with compensated shock may risk undertriage …

Hypotension begins at 110 mm Hg: redefining “hypotension” with data

BJ Eastridge, J Salinas, JG McManus… - Journal of Trauma …, 2007 - journals.lww.com
Background: Clinicians routinely refer to hypotension as a systolic blood pressure (SBP)≤
90 mm Hg. However, few data exist to support the rigid adherence to this arbitrary cutoff. We …

Lactate is a better predictor than systolic blood pressure for determining blood requirement and mortality: could prehospital measures improve trauma triage?

MJ Vandromme, RL Griffin, JA Weinberg… - Journal of the American …, 2010 - Elsevier
BACKGROUND: Standard hemodynamic evaluation of patients in shock may underestimate
severity of hemorrhage given physiologic compensation. Blood lactate (BL) is an important …

Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial

EM Bulger, GJ Jurkovich, AB Nathens… - Archives of …, 2008 - jamanetwork.com
Background The leading cause of late mortality after trauma is multiple organ failure
syndrome, due to a dysfunctional inflammatory response early after injury. Preclinical …

Heart rate: is it truly a vital sign?

KJ Brasel, C Guse, LM Gentilello… - Journal of Trauma and …, 2007 - journals.lww.com
Background: Tachycardia, often defined as heart rate> 100 bpm, has been utilized as a
physical sign of hypovolemic shock among the injured for decades without evidence to …

Estimation of individual-specific progression to impending cardiovascular instability using arterial waveforms

VA Convertino, G Grudic, J Mulligan… - Journal of Applied …, 2013 - journals.physiology.org
Trauma patients with “compensated” internal hemorrhage may not be identified with
standard medical monitors until signs of shock appear, at which point it may be difficult or too …

Pulse decomposition analysis of the digital arterial pulse during hemorrhage simulation

MC Baruch, DER Warburton, SSD Bredin… - Nonlinear biomedical …, 2011 - Springer
Background Markers of temporal changes in central blood volume are required to non-
invasively detect hemorrhage and the onset of hemorrhagic shock. Recent work suggests …

Physiological and medical monitoring for en route care of combat casualties

VA Convertino, KL Ryan, CA Rickards… - Journal of Trauma …, 2008 - journals.lww.com
Background: Most prehospital medical interventions during civilian and military trauma
casualty transport fail to utilize advanced decision-support systems for treatment and …