Multiple sclerosis (MS) is characterized by autoimmune inflammation and subsequent
neurodegeneration. It is believed that early in the disease course, proinflammatory T cells …

Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system
that often leads to disability in young adults. Treatment options are limited and often only …

Background Interferon beta is used to modify the course of relapsing multiple sclerosis.
Despite interferon beta therapy, many patients have relapses. Natalizumab, an α4 integrin …

The protein kinase Cθ (PKCθ) serine/threonine kinase has been implicated in signaling of T
cell activation, proliferation, and cytokine production. However, the in vivo consequences of …

Objective: This study evaluated the efficacy and safety of ATL1102, an antisense
oligonucleotide that selectively targets the RNA for human CD49d, the α subunit of very late …

The objective of the current study was to investigate whether minocycline improves the effect
of an existing multiple sclerosis (MS) medication, interferon-β, on experimental autoimmune …

[Frontiers in Bioscience 9, 3242-3247, September 1, 2004] 3242 IFN-BETA IN RHEUMATOID
ARTHRITIS Paul P. Tak Division of Clinical Page 1 [Frontiers in Bioscience 9, 3242-3247 …

New “omic” technologies and their application to systems biology approaches offer new
opportunities for biomarker discovery in complex disorders, including multiple sclerosis …

Interferon-beta (IFN-β) reduces disease activity in a subgroup of patients with relapsing
remitting multiple sclerosis (MS). The mechanism of action as well as the pathophysiological …

Multiple sclerosis is a chronic autoimmune disease of the central nervous system for which a
number of disease-modifying therapies are available, including interferon beta (Avonex® …