Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Polycystic kidney disease is typified by cysts in the kidney and extra-renal manifestations
including hypertension and heart failure. The main genetic underpinning this disease are …

Oxidative-stress-induced apoptosis of granulosa cells is considered to be a main driver of
follicular atresia. Increasing evidence suggests a protective effect of melatonin against …

BACKGROUND: The cardiac-protective role of GSNOR (S-nitrosoglutathione reductase) in
the cytoplasm, as a denitrosylase enzyme of S-nitrosylation, has been reported in cardiac …

ABSTRACT NPPA/atrial natriuretic peptide (natriuretic peptide type A) exerts critical
pleiotropic effects in the cardiovascular system, limiting cardiomyocyte hypertrophy and …

FMS‐like receptor tyrosine kinase 3 (Flt3) expression was reported to increase in the heart
in response to pathological stress, but the role of Flt3 activation and its underlying …

The progressive formation of single or multiple cysts accompanies several renal diseases.
Specifically,(i) genetic forms, such as adult dominant polycystic kidney disease (ADPKD) …

Heart disease is one of the leading causes of death in autosomal dominant polycystic kidney
disease (ADPKD) patients. Left ventricular hypertrophy (LVH) is an early and severe …

Polycystic kidney disease (PKD) is the most common genetic form of chronic kidney disease
(CKD), and it involves the development of multiple kidney cysts. Not enough medical …

The development of skeletal muscle (myogenesis) is a well-orchestrated process where
myoblasts withdraw from the cell cycle and differentiate into myotubes. Signaling by fluxes in …