Per‐and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research

SE Fenton, A Ducatman, A Boobis… - Environmental …, 2021 - Wiley Online Library
Reports of environmental and human health impacts of per‐and polyfluoroalkyl substances
(PFAS) have greatly increased in the peer‐reviewed literature. The goals of the present …

[HTML][HTML] Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms

ME Andersen, B Hagenbuch, U Apte, JC Corton… - Toxicology, 2021 - Elsevier
Serum concentrations of cholesterol are positively correlated with exposure to
perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) in humans. The …

[HTML][HTML] The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice

Y Fan, RK Støving, S Berreira Ibraim… - Nature …, 2023 - nature.com
Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are
women and it has a population prevalence of about 1%, but evidence-based treatment is …

[HTML][HTML] Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

P Sen, S Qadri, PK Luukkonen, O Ragnarsdottir… - Journal of …, 2022 - Elsevier
Background & aims Recent experimental models and epidemiological studies suggest that
specific environmental contaminants (ECs) contribute to the initiation and pathology of non …

Risk to human health related to the presence of perfluoroalkyl substances in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluoroalkyl substances (PFAS s) in food. Based …

Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water

Y Li, L Barregard, Y Xu, K Scott, D Pineda… - Environmental …, 2020 - Springer
Background Exposures to perfluoroalkyl substances (PFAS) have shown positive
associations with serum lipids in previous studies. While many studies on lipids investigated …

Paired liver: plasma PFAS concentration ratios from adolescents in the Teen-LABS study and derivation of empirical and mass balance models to predict and explain …

BO Baumert, FC Fischer, F Nielsen… - … science & technology, 2023 - ACS Publications
Animal studies have pointed at the liver as a hotspot for per-and polyfluoroalkyl substances
(PFAS) accumulation and toxicity; however, these findings have not been replicated in …

Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes

S Lamichhane, P Sen, AM Dickens, MA Alves… - Cell Reports …, 2022 - cell.com
The gut microbiota is crucial in the regulation of bile acid (BA) metabolism. However, not
much is known about the regulation of BAs during progression to type 1 diabetes (T1D) …

[HTML][HTML] Associations between perfluoroalkyl substances and lipid profile in a highly exposed young adult population in the Veneto Region

C Canova, G Barbieri, MZ Jeddi, M Gion… - Environment …, 2020 - Elsevier
Background Residents of a large area of the Veneto Region (North-Eastern Italy) were
exposed for decades to drinking water contaminated by perfluoroalkyl substances (PFAS) …

Legacy and Emerging Per- and Polyfluoroalkyl Substances Surveillance in Bufo gargarizans from Inlet Watersheds of Chaohu Lake, China: Tissue Distribution and …

Y Shu, Q Wang, P Hong, Y Ruan, H Lin… - Environmental …, 2023 - ACS Publications
Amphibians are sensitive biomonitors of environmental pollutants but reports regarding per-
and polyfluoroalkyl substances (PFAS), a class of synthetic organofluorine substances, are …