Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Glycosphingolipids (GSL s) comprise a heterogeneous group of membrane lipids formed by
a ceramide backbone covalently linked to a glycan moiety. Hundreds of different glycans …

Increased expression of SIRT 1 extends the lifespan of lower organisms and delays the
onset of age‐related diseases in mammals. Here, we show that SRT 2104, a synthetic small …

Altered levels of sphingolipids and their metabolites in the brain, and the related
downstream effects on neuronal homeostasis and the immune system, provide a framework …

Adult stem cells constitute an important reservoir of self-renewing progenitor cells and are
crucial for maintaining tissue and organ homeostasis. The capacity of stem cells to self …

Signaling by the transforming growth factor–β (TGF-β) receptors I and II (TβRI/II) and the
primary cilia-localized sonic hedgehog (Shh) pathway promote cell migration and …

Glycosphingolipids (GSLs) are a class of ceramide-based glycolipids essential for embryo
development in mammals. The synthesis of specific GSLs depends on the expression of …

Lipids are often considered membrane components whose function is to embed proteins
into cell membranes. In the last two decades, studies on brain lipids have unequivocally …

The abundance and structural diversity of glycans on glycoproteins and glycolipids are
highly regulated and play important roles during vertebrate development. Because of the …

Human mesenchymal stem/stromal cells (hMSC) are increasingly used in advanced cellular
therapies. The clinical use of hMSCs demands sequential cell expansions. As it is well …