One-pot synthesis of novel poly-substituted 3-cyanopyridines: Molecular docking, antimicrobial, cytotoxicity, and DFT/TD-DFT studies
Abstract Novel pyridine-3-carbonitrile derivatives, denoted as (4a-j), were synthesized using
a convergent synthetic approach that involved a one-pot four-component reaction. This was …
a convergent synthetic approach that involved a one-pot four-component reaction. This was …
Synthesis and Anticancer Activity of Novel Derivatives of α,β‐Unsaturated Ketones Based on Oleanolic Acid: in Vitro and in Silico Studies against Prostate Cancer …
H Şenol, M Ghaffari‐Moghaddam, Ş Bulut… - Chemistry & …, 2023 - Wiley Online Library
Herein, new derivatives of α, β‐unsaturated ketones based on oleanolic acid (4 a–i) were
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …
Bioactive plant waste components targeting oral bacterial pathogens as a promising strategy for biofilm eradication
S Mashal, A Siddiqua, N Ullah, R Baloch… - Frontiers in …, 2024 - frontiersin.org
The significance of this study lies in its exploration of bioactive plant extracts as a promising
avenue for combating oral bacterial pathogens, offering a novel strategy for biofilm …
avenue for combating oral bacterial pathogens, offering a novel strategy for biofilm …
Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment
Malaria remains a major public health problem worldwide, including in Southeast Asia.
Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug …
Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug …
[PDF][PDF] EXPLORATION OF THE ACTIVE COMPOUNDS OF MORINGA OLEIFERA LAM AS HIV-1 REVERSE TRANSCRIPTASE INHIBITOR: A NETWORK …
M FITRIANA, A MUN'IM, WA FIRDAYANI - Int J App Pharm, 2024 - academia.edu
Objective: This study aims to predict the active compound of Moringa oleifera for the
treatment of Human Immunodeficiency Virus (HIV), specifically targeting the HIV-1 reverse …
treatment of Human Immunodeficiency Virus (HIV), specifically targeting the HIV-1 reverse …
Designing, Docking, Molecular Dynamics of Several Aminocoumarin Analogues to Predict Solution of Aminocoumarin Derivatives Issues: Poor Oral-Bioavailability …
M Al-Amin, MA Haque - 2023 - researchsquare.com
Aminocoumarin derivatives such as Novobiocin, Coumermycin, and Clorobiocin have
several issues: poor oral bioavailability, low solubility, and toxicity. The Food and Drug …
several issues: poor oral bioavailability, low solubility, and toxicity. The Food and Drug …
[引用][C] Exploring the Relationship between PheSA Scores and Ligand Efficiency in the Discovery of Potent Antimalarials: A Computational Perspective
AO Ayodele, OJ Ayodele, S Nasiru, WI Musa… - Journal of Tropical …, 2024