Role of GATA3 in tumor diagnosis: A review

MK Najafabadi, E Mirzaeian, SM Montazerin… - … -Research and Practice, 2021 - Elsevier
Abstract GATA binding protein 3 (GATA3) belongs to a family of transcription factors
comprising six members. These proteins identify GATA containing sequences in the target …

The role of GATA3 in breast carcinomas: a review

R Asch-Kendrick, A Cimino-Mathews - Human pathology, 2016 - Elsevier
GATA3 is a zinc-binding transcription factor that regulates the differentiation of many human
tissue types, including the mammary gland. In surgical pathology, immunohistochemistry for …

GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas

A Cimino-Mathews, AP Subhawong, PB Illei, R Sharma… - Human pathology, 2013 - Elsevier
GATA3 plays an integral role in breast luminal cell differentiation and is implicated in breast
cancer progression. GATA3 immunohistochemistry is a useful marker of breast cancer; …

[PDF][PDF] GATA3 expression in human tumors: a tissue microarray study on 16,557 tumors

V Reiswich, CE Schmidt, M Lennartz, D Höflmayer… - Pathobiology, 2023 - karger.com
Introduction: GATA3 is a transcription factor involved in epithelial cell differentiation. GATA3
immunostaining is used as a diagnostic marker for breast and urothelial cancer but can also …

[HTML][HTML] GATA3 mediates doxorubicin resistance by inhibiting CYB5R2-catalyzed iron reduction in breast cancer cells

Z Zhu, H Shen, J Xu, Z Fang, G Wo, Y Ma, K Yang… - Drug Resistance …, 2023 - Elsevier
Aims Neoadjuvant chemotherapy (NAC) is the primary preoperative therapy for breast
cancer. The luminal subtype of breast cancer shows less NAC response than the basal …

GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary and metastatic breast cancer

YB Ni, JYS Tsang, MM Shao, SK Chan… - Breast cancer research …, 2018 - Springer
Purpose Despite numerous studies on the utility of GATA-3 as breast cancer marker, its
comparison with other breast markers, its concordance between primary and metastatic …

[HTML][HTML] MicroRNA regulation of molecular pathways as a generic mechanism and as a core disease phenotype

R Ben-Hamo, S Efroni - Oncotarget, 2015 - ncbi.nlm.nih.gov
The role of microRNAs as key regulators of a wide variety of fundamental cellular processes,
such as apoptosis, differentiation, proliferation and cell cycle is increasingly recognized in …

GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

LA Callender, J Schroth, EC Carroll… - Nature …, 2021 - nature.com
GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4+ T
helper 2 (Th2) cells, but is also involved in a variety of processes such as immune …

Utility of GATA3 immunohistochemistry for diagnosis of metastatic breast carcinoma in cytology specimens

DR Braxton, C Cohen, MT Siddiqui - Diagnostic Cytopathology, 2015 - Wiley Online Library
Background GATA3 as a diagnostic marker of metastatic breast carcinoma in cytology
specimens has not been fully established. Methods Metastatic breast carcinoma was …

GATA3 somatic mutations are associated with clinicopathological features and expression profile in TCGA breast cancer patients

F Afzaljavan, AS Sadr, S Savas, A Pasdar - Scientific reports, 2021 - nature.com
The effect of somatic mutations and the gene expression profiles on the prognosis is well
documented in cancer research. This study was conducted to evaluate the association of …