Pancreatic cancer: a review of current treatment and novel therapies

HM Kolbeinsson, S Chandana, GP Wright… - Journal of Investigative …, 2023 - Taylor & Francis
Pancreatic cancer is one of the leading causes for cancer-related deaths in the United
States. Majority of patients present with unresectable or metastatic disease. For those that …

Neoadjuvant treatment in pancreatic cancer

A Oba, F Ho, QR Bao, MH Al-Musawi… - Frontiers in …, 2020 - frontiersin.org
Thanks to the development of modern chemotherapeutic regimens, survival after surgery for
pancreatic ductal adenocarcinoma (PDAC) has improved and pancreatologists worldwide …

Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the Dutch randomized phase III …

E Versteijne, M Suker, K Groothuis… - Journal of clinical …, 2020 - ascopubs.org
PURPOSE Preoperative chemoradiotherapy may improve the radical resection rate for
resectable or borderline resectable pancreatic cancer, but the overall benefit is unproven …

Oncological benefits of neoadjuvant chemoradiation with gemcitabine versus upfront surgery in patients with borderline resectable pancreatic cancer: a prospective …

JY Jang, Y Han, H Lee, SW Kim, W Kwon… - Annals of …, 2018 - journals.lww.com
Objective: This study was performed to determine whether neoadjuvant treatment increases
survival in patients with BRPC. Summary Background Data: Despite many promising …

Pancreatic adenocarcinoma, version 2.2017, NCCN clinical practice guidelines in oncology

MA Tempero, MP Malafa, M Al-Hawary… - Journal of the National …, 2017 - jnccn.org
Ductal adenocarcinoma and its variants account for most pancreatic malignancies. High-
quality multiphase imaging can help to preoperatively distinguish between patients eligible …

Potentially curable pancreatic cancer: American Society of Clinical Oncology clinical practice guideline

AA Khorana, PB Mangu, J Berlin… - Journal of Clinical …, 2016 - ascopubs.org
Purpose To provide evidence-based recommendations to oncologists and others on
potentially curative therapy for patients with localized pancreatic cancer. Methods ASCO …

Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head

DB Evans, GR Varadhachary, CH Crane… - Journal of Clinical …, 2008 - ascopubs.org
Purpose We conducted a phase II trial to assess the outcomes of patients who received
preoperative gemcitabine-based chemoradiation and pancreaticoduodenectomy (PD) for …

The concurrent chemoradiation paradigm—general principles

TY Seiwert, JK Salama, EE Vokes - Nature clinical practice Oncology, 2007 - nature.com
During the past 20 years, the advent of neoadjuvant, primary, and adjuvant concurrent
chemoradiotherapy has improved cancer care dramatically. Significant contributions have …

Irreversible electroporation therapy in the management of locally advanced pancreatic adenocarcinoma

RCG Martin II, K McFarland, S Ellis… - Journal of the American …, 2012 - Elsevier
BACKGROUND: Locally advanced pancreatic cancer patients have limited options for
disease control. Local ablation technologies based on thermal damage have been used but …

Meta-analysis of radical resection rates and margin assessment in pancreatic cancer

MD Chandrasegaram, D Goldstein… - Journal of British …, 2015 - academic.oup.com
Background R0 resection rates (complete tumour removal with negative resection margins)
in pancreatic cancer are 70–80 per cent when a 0-mm margin is used, declining to 15–24 …