malERA: an updated research agenda for malaria elimination and eradication
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …
overwhelming health, equity, and economic benefits. WHO and countries are setting …
Advances in molecular genetic systems in malaria
Robust tools for analysing gene function in Plasmodium parasites, which are the causative
agents of malaria, are being developed at an accelerating rate. Two decades after genetic …
agents of malaria, are being developed at an accelerating rate. Two decades after genetic …
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite
burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on …
burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on …
GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing
M Filarsky, SA Fraschka, I Niederwieser… - Science, 2018 - science.org
Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each
replication cycle, some parasites differentiate into gametocytes, the only forms able to infect …
replication cycle, some parasites differentiate into gametocytes, the only forms able to infect …
A genetic system to study Plasmodium falciparum protein function
J Birnbaum, S Flemming, N Reichard, AB Soares… - Nature …, 2017 - nature.com
Current systems to study essential genes in the human malaria parasite Plasmodium
falciparum are often inefficient and time intensive, and they depend on the genetic …
falciparum are often inefficient and time intensive, and they depend on the genetic …
PTEX is an essential nexus for protein export in malaria parasites
B Elsworth, K Matthews, CQ Nie, M Kalanon… - Nature, 2014 - nature.com
During the blood stages of malaria, several hundred parasite-encoded proteins are exported
beyond the double-membrane barrier that separates the parasite from the host cell …
beyond the double-membrane barrier that separates the parasite from the host cell …
Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle
P Favuzza, M de Lera Ruiz, JK Thompson, T Triglia… - Cell host & …, 2020 - cell.com
Artemisin combination therapy (ACT) is the main treatment option for malaria, which is
caused by the intracellular parasite Plasmodium. However, increased resistance to ACT …
caused by the intracellular parasite Plasmodium. However, increased resistance to ACT …
Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
Synthetic posttranscriptional regulation of gene expression is important for understanding
fundamental biology and programming new cellular processes in synthetic biology. Previous …
fundamental biology and programming new cellular processes in synthetic biology. Previous …
Generating conditional gene knockouts in Plasmodium – a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR/Cas9
Successful establishment of CRISPR/Cas9 genome editing technology in Plasmodium spp.
has provided a powerful tool to transform Plasmodium falciparum into a genetically more …
has provided a powerful tool to transform Plasmodium falciparum into a genetically more …
The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching
VM Schneider, JE Visone, CT Harris… - Proceedings of the …, 2023 - National Acad Sciences
The primary antigenic and virulence determinant of the human malaria parasite Plasmodium
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …