Phosphorylation is a key regulator of protein function under (patho) physiological conditions,
and defining site‐specific phosphorylation is essential to understand basic and disease …

Alteration of O-GlcNAcylation, a dynamic posttranslational modification, is associated with
tumorigenesis and tumor progression. Its role in chemotherapy response is poorly …

Bacterial thymidylate kinase (TMK) is a member of nucleoside monophosphate kinases and
recently becomes a protein of interest in the discovery of new antibacterial agents …

Thymidylate synthase (TS) catalyzes the production of the nucleotide dTMP from
deoxyuridine monophosphate (dUMP), making the enzyme necessary for DNA replication …

Protein phosphorylation is a ubiquitous post-translational modification (PTM) that regulates
all aspects of life. To date, investigation of human cell signalling has focussed on canonical …

Thymidylate Synthase (TSase) is a highly conserved enzyme that catalyzes the production
of the DNA building block thymidylate. Structurally, functionally and mechanistically …

Background/Aim: Recently, we demonstrated the ability of inhibitors of protein kinase 2
(casein kinase II; CK2) to enhance the efficacy of 5-fluorouracil, a thymidylate synthase …

Endogenous thymidylate synthases, isolated from tissues or cultured cells of the same
specific origin, have been reported to show differing slow-binding inhibition patterns. These …

Cystathionine beta‐synthase‐deficient homocystinuria (HCU) is a life‐threatening disorder
of sulfur metabolism. HCU can be treated by using betaine to lower tissue and plasma levels …

Thymidylate synthase (TS), dihydrofolate reductase (DHFR), and serine
hydroxymethyltransferase (SHMT) constitute the thymidylate synthesis cycle providing …