Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

KJ Wicht, S Mok, DA Fidock - Annual review of microbiology, 2020 - annualreviews.org
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …

Heme detoxification in the malaria parasite: A target for antimalarial drug development

KA de Villiers, TJ Egan - Accounts of chemical research, 2021 - ACS Publications
Conspectus Over the last century, malaria deaths have decreased by more than 85%.
Nonetheless, there were 405 000 deaths in 2018, mostly resulting from Plasmodium …

Tautomerism unveils a self-inhibition mechanism of crystallization

W Tang, T Yang, CA Morales-Rivera, X Geng… - Nature …, 2023 - nature.com
Modifiers are commonly used in natural, biological, and synthetic crystallization to tailor the
growth of diverse materials. Here, we identify tautomers as a new class of modifiers where …

Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations

S Farah, JC Doloff, P Müller, A Sadraei, HJ Han… - Nature materials, 2019 - nature.com
Implantable medical devices have revolutionized modern medicine. However, immune-
mediated foreign body response (FBR) to the materials of these devices can limit their …

Molecular modifiers reveal a mechanism of pathological crystal growth inhibition

J Chung, I Granja, MG Taylor, G Mpourmpakis… - Nature, 2016 - nature.com
Crystalline materials are crucial to the function of living organisms, in the shells of molluscs,,,
the matrix of bone, the teeth of sea urchins, and the exoskeletons of coccoliths. However …

[HTML][HTML] Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity

ACC Aguiar, E Murce, WA Cortopassi… - International Journal for …, 2018 - Elsevier
In spite of recent efforts to eradicate malaria in the world, this parasitic disease is still
considered a major public health problem, with a total of 216 million cases of malaria and …

[HTML][HTML] Drug targets for resistant malaria: historic to future perspectives

S Kumar, TR Bhardwaj, DN Prasad… - Biomedicine & …, 2018 - Elsevier
New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Basic Nitrogen (BaN) is a key property of antimalarial chemical space

H Valluri, A Bhanot, S Shah, N Bhandaru… - Journal of Medicinal …, 2023 - ACS Publications
Most antimalarials are based on basic N-heterocycles and possess amine functionalities.
Despite this, the role of basic nitrogen (BaN) in antimalarial drug design has not been …

Engineering crystal modifiers: bridging classical and nonclassical crystallization

KN Olafson, R Li, BG Alamani, JD Rimer - Chemistry of Materials, 2016 - ACS Publications
The use of growth modifiers in natural, biological, and synthetic crystallization is a ubiquitous
strategy for controlling growth and achieving desired physicochemical properties. For …

Molecular imposters functioning as versatile growth modifiers of urate crystallization

W Tang, C Smith, CB Parry, J Meegan… - Crystal Growth & …, 2023 - ACS Publications
Interactions between molecular modifiers and crystal surfaces govern numerous processes
and structural outcomes of natural, biological, and synthetic crystallization. An efficient …