Abstract Three-dimensional (3D) in vitro models have been used in cancer research as an
intermediate model between in vitro cancer cell line cultures and in vivo tumor. Spherical …

The re-creation of the tumor microenvironment including tumor–stromal interactions, cell–
cell adhesion and cellular signaling is essential in cancer-related studies. Traditional two …

Bladder cancer is a common malignancy that has a relatively poor outcome. Lack of culture
models for the bladder epithelium (urothelium) hampers the development of new …

One of the exciting aspects of being involved in the field of molecular biology is the ever-
accelerating rate of progress, both in the development of new methodologies and the …

Simple Summary Primary culture of cancer cells from patient tumors in a physiologically
relevant system can provide information about tumor biology, disentangle the role of …

Experimental urinary bladder tumours have been proposed as a useful model for the study
of urinary bladder carcinogenesis, as well as for evaluating new therapeutic strategies …

Bladder-related diseases are among the most common and costly to the healthcare system,
and therefore require new approaches to treatment. Organoids and spheroids are 3D …

Bladder cancer is a common malignancy in the urinary tract. Despite different therapeutic
options, recurrence and progression of urothelial carcinoma after treatment is not …

Nearly three-quarters of all newly diagnosed urothelial cancers are non-muscle-invasive
bladder cancers (NMIBCs). Although bladder-preserving surgery can be used to treat …

Bladder cancer (BC) is the sixth most common worldwide urologic malignancy associated
with elevated morbidity and mortality rates if not well treated. The muscle-invasive form of …