The Ras-responsive element binding protein 1 (RREB1) is a member of zinc finger
transcription factors, which is widely involved in biological processes including cell …

A key to the development of improved pharmacological treatment strategies for cancer is an
understanding of the integration of biochemical pathways involved in both tumorigenesis …

Although activating mutations in RAS oncogenes are known to result in aberrant signaling
through multiple pathways, the role of microRNAs (miRNAs) in the Ras oncogenic program …

The androgen receptor (AR) is a key regulator of prostate tumorgenesis through actions that
are not fully understood. We identified the repressor element (RE)-1 silencing transcription …

A lack of expression of miR-143 and miR-145 has been demonstrated to be a frequent
feature of colorectal tumors. Activating KRAS mutations have been reported in 30–60% of …

Background Prostate cancer threatens the health of men over sixty years old, and its
incidence ranks first among all urinary tumors among men. Enzalutamide remains the first …

Gene expression programs required for differentiation depend on both DNA-bound
transcription factors and surrounding histone modifications. Expression of the basic helix …

In eukaryotes, karyopherin β superfamily proteins mediate nucleocytoplasmic transport of
macromolecules. We investigated the evolutionary and transcriptional patterns of these …

Studies of induced granulocytic differentiation help to reveal molecular mechanisms of cell
maturation. The nuclear proteome represents a rich source of regulatory molecules …

Pancreatic adenocarcinoma is an untreatable deadly cancer. The factors involved in its early
development remain unknown; which contributes to the absence of biomarkers for early …