Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization …

The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …

The spatial organization of cells depends on their ability to sense their own shape and size.
Here, we investigate how cell shape affects the positioning of the nucleus, spindle and …

Mechanical properties of the nuclear envelope have implications for cell and nuclear
architecture as well as gene regulation. Using isolated Xenopus oocyte nuclei, we have …

Increasing evidence suggests functional compartmentalization of interphase nuclei [1]. This
includes preferential interior localization of gene-rich and early replicating chromosome …

Nuclear receptors regulate many biologically important processes in development and
homeostasis by their bimodal function as repressors and activators of gene transcription. A …

The presence of actin and nuclear myosin I (NMI) in the nucleus suggests a role for these
motor proteins in nuclear functions. We have investigated the role of actin and nuclear …

Actin is abundant in the nucleus and has been implicated in transcription; however, the
nature of this involvement has not been established. Here we demonstrate that β-actin is …

Polycomb group protein Ezh2, one of the key regulators of development in organisms from
flies to mice, exerts its epigenetic function through regulation of histone methylation. Here …

This review surveys what is known about the structure and function of the subnuclear
domains called Cajal bodies (CBs). The major focus is on CBs in mammalian cells but we …