The emergence of multi-drug resistance makes bacterial infection a major threat to public
health and economy. The formation of bacterial biofilms is one of the main reasons of …

Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of
nanotechnology applied in the biomedical field, due to their easily tunable structure and …

Traditional antibiotic treatment has limited efficacy for the drug-tolerant bacteria present in
biofilms because of their unique metabolic conditions in the biofilm infection …

Hypoxia, as a characteristic feature of solid tumors, has a close relationship with tumor
resistance to photodynamic therapy (PDT) and chemotherapy. Perfluorocarbon (PFC) is …

Nanotechnology enlightens promising antibacterial strategies while the complex in vivo
infection environment poses a great challenge to the rational design of nanoplatforms for …

The formation of biofilms is closely associated with persistent and chronic infections, and
physiological heterogeneity such as pH and oxygen gradients renders biofilms highly …

Abstract Treatment of bacterial biofilms remains a great challenge in the clinic. Recently,
ultrasound (US)-driven antimicrobial sonodynamic therapy (aSDT) has been considered as …

The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections,
especially biofilms and accompanying inflammation, has recently aroused widespread …

Nitric oxide (NO) serves as a key regulator of many physiological processes and as a potent
therapeutic agent. The local delivery of NO is important to achieve target therapeutic …

Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or
anticarcinogens that present a general killing mechanism through the physical disruption of …