[HTML][HTML] Human disorders of peroxisome metabolism and biogenesis

HR Waterham, S Ferdinandusse… - Biochimica Et Biophysica …, 2016 - Elsevier
Peroxisomes are dynamic organelles that play an essential role in a variety of cellular
catabolic and anabolic metabolic pathways, including fatty acid alpha-and beta-oxidation …

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease

S Paul, GI Lancaster, PJ Meikle - Progress in lipid research, 2019 - Elsevier
Plasmalogens are a class of membrane glycerophospholipids with unique properties. They
contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and …

Biochemistry of mammalian peroxisomes revisited

RJA Wanders, HR Waterham - Annu. Rev. Biochem., 2006 - annualreviews.org
In this review, we describe the current state of knowledge about the biochemistry of
mammalian peroxisomes, especially human peroxisomes. The identification and …

Mechanisms of plant salt response: insights from proteomics

H Zhang, B Han, T Wang, S Chen, H Li… - Journal of proteome …, 2012 - ACS Publications
Soil salinity is a major abiotic stress that limits plant growth and agriculture productivity. To
cope with salt stress, plants have evolved complex salt-responsive signaling and metabolic …

Zellweger spectrum disorders: clinical overview and management approach

FCC Klouwer, K Berendse, S Ferdinandusse… - Orphanet journal of rare …, 2015 - Springer
Zellweger spectrum disorders (ZSDs) represent the major subgroup within the peroxisomal
biogenesis disorders caused by defects in PEX genes. The Zellweger spectrum is a clinical …

Functions and biosynthesis of plasmalogens in health and disease

P Brites, HR Waterham, RJA Wanders - … BBA)-Molecular and Cell Biology of …, 2004 - Elsevier
Plasmalogens (1-O-alk-1′-enyl-2-acyl glycerophospholipids) constitute a special class of
phospholipids characterized by the presence of a vinyl–ether bond at the sn-1 position …

[HTML][HTML] Genetics and molecular basis of human peroxisome biogenesis disorders

HR Waterham, MS Ebberink - … et Biophysica Acta (BBA)-Molecular Basis of …, 2012 - Elsevier
Human peroxisome biogenesis disorders (PBDs) are a heterogeneous group of autosomal
recessive disorders comprised of two clinically distinct subtypes: the Zellweger syndrome …

Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5

GJ Gatto, BV Geisbrecht, SJ Gould, JM Berg - Nature structural biology, 2000 - nature.com
Many proteins contain targeting signals within their sequences that specify their delivery to
particular organelles. The peroxisomal targeting signal-1 (PTS1) is a C-terminal tripeptide …

The Arabidopsis pxa1 Mutant Is Defective in an ATP-Binding Cassette Transporter-Like Protein Required for Peroxisomal Fatty Acid β-Oxidation

BK Zolman, ID Silva, B Bartel - Plant Physiology, 2001 - academic.oup.com
Peroxisomes are important organelles in plant metabolism, containing all the enzymes
required for fatty acid β-oxidation. More than 20 proteins are required for peroxisomal …

[HTML][HTML] Hair follicle stem cell-specific PPARγ deletion causes scarring alopecia

P Karnik, Z Tekeste, TS McCormick, AC Gilliam… - Journal of Investigative …, 2009 - Elsevier
Primary cicatricial or scarring alopecias (CA) are a group of inflammatory hair disorders of
unknown pathogenesis characterized by the permanent destruction of the hair follicle. The …