Rationale: Matrix vesicles (MVs), secreted by vascular smooth muscle cells (VSMCs), form
the first nidus for mineralization and fetuin-A, a potent circulating inhibitor of calcification, is …

Pathological mineralization has been reported countless times in the literature and is a well-
known phenomenon in the medical field for its connections to a wide range of diseases …

The understanding of vascular calcification-based mechanism is an urgent pending task in
vascular biology and this prompted us to better address this issue by investigating whether …

Background Normal and calcified human valve cusps, coronary arteries, and aortae harbor
spherical calcium phosphate microparticles of identical composition and crystallinity, and …

Résumé Out of several concurrent hypotheses that attempt to explain the development of
calcific lesions in vascular tissues, the most widely accepted is based on the formation of …

Scanning Electron Microscopy (SEM) is widely used as a technique for materials
characterization. It has also been successfully applied to the imaging of biological samples …

The vascular system is responsible for transporting cells and nutrients throughout the body.
It is a dynamic tissue with exceptional physiological activities, but which is subject to the …

The formation of calcium phosphate (calcification) has been observed in a variety of healthy
and diseased tissues and contributes to a wide range of pathologies. In physiological and …

While osteoarthritis (OA) involves pathological cartilage calcification, its progress is not fully
understood. Here, we investigated the temporal-spatial mechanism of mineral …

Scanning electron microscopy (SEM) is widely used for materials characterization. It has
also been successfully applied to the imaging of biological samples, providing invaluable …