Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy

K Liu, X Zhang, L Xie, M Deng, H Chen, J Song… - Pharmacological …, 2021 - Elsevier
Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and
medicinal plants. In the last decade, a plethora of studies on the pharmacological activities …

A review on pharmacological activities of lupeol and its triterpene derivatives

N Sharma, P Palia, A Chaudhary, K Verma… - Journal of Drug …, 2020 - jddtonline.info
Lupeol is a pentacyclic triterpenoid commonly distributed in the plant kingdom and is found
in edible fruits and vegetables. It is a naturally occurring triterpene that is used to reduce the …

Structural characterization of water-soluble polysaccharide from Arctium lappa and its effects on colitis mice

Y Wang, N Zhang, J Kan, X Zhang, X Wu, R Sun… - Carbohydrate …, 2019 - Elsevier
In this study, water-soluble polysaccharide from Arctium lappa was extracted, isolated and
purified to be a fraction (ALP-1). Characterization of structure revealed that ALP-1 was a kind …

[HTML][HTML] Protective effects of Ligularia fischeri root extracts against ulcerative colitis in mice through activation of Bcl-2/Bax signalings

YP Fu, H Yuan, Y Xu, RM Liu, Y Luo, JH Xiao - Phytomedicine, 2022 - Elsevier
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by
high levels of proinflammatory cytokines and epithelial barrier dysfunction. The root of …

Rape bee pollen alleviates dextran sulfate sodium (DSS)-induced colitis by neutralizing IL-1β and regulating the gut microbiota in mice

S Chen, H Zhao, N Cheng, W Cao - Food research international, 2019 - Elsevier
Colitis is a major chronic disease in today's society. Consumption of phenolic compounds
can protect against colitis. We examined the phenolic compounds of rape bee pollen extract …

The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach

AU Khan, A Khan, B Shal, S Khan, M Khan… - Phytotherapy …, 2023 - Wiley Online Library
Cancer is the leading cause of mortality and morbidity worldwide, and its cases are rapidly
increasing every year. Several factors contribute to the development of tumorigenesis …

Health benefits of 4, 4-dimethyl phytosterols: An exploration beyond 4-desmethyl phytosterols

T Zhang, R Liu, M Chang, Q Jin, H Zhang, X Wang - Food & function, 2020 - pubs.rsc.org
4, 4-Dimethyl phytosterols possess two methyl groups at the carbon-4 atom of the aliphatic A-
ring. The methyl groups are crucial for the molecular recognition of endogenous and …

[HTML][HTML] Protein kinase Cα–mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it

R Tedja, CM Roberts, AB Alvero, C Cardenas… - Journal of Biological …, 2019 - ASBMB
Twist1 is a basic helix-loop-helix transcription factor that plays a key role in embryonic
development, and its expression is down-regulated in adult cells. However, Twist1 is highly …

Oral delivery of a Lactococcus lactis strain secreting bovine lactoferricin–lactoferrampin alleviates the development of acute colitis in mice

L Song, W Xie, Z Liu, D Guo, D Zhao, X Qiao… - Applied microbiology …, 2019 - Springer
Ulcerative colitis (UC) is a chronic relapsing disease. Treatment of UC would benefit from
specific targeting of therapeutics to the intestine. Previous studies have demonstrated that …

Pectin–zein based stigmasterol nanodispersions ameliorate dextran sulfate sodium-induced colitis in mice

S Feng, M Sui, D Wang, C Ritzoulis, MA Farag… - Food & Function, 2021 - pubs.rsc.org
Due to the insolubility of phytosterols in both water and oil, their application in the medicine
and health and food industries is limited. In this study, zein and pectin were selected as wall …