Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
JK Gjerstad, SL Lightman, F Spiga - Stress, 2018 - Taylor & Francis
The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …
Is the HPA axis as target for depression outdated, or is there a new hope?
A Menke - Frontiers in psychiatry, 2019 - frontiersin.org
Major depressive disorder (MDD) is a very common stress-related mental disorder that
carries a huge burden for affected patients and the society. It is associated with a high …
carries a huge burden for affected patients and the society. It is associated with a high …
Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders
EB Binder - Psychoneuroendocrinology, 2009 - Elsevier
FK506 binding protein 51 or FKBP5 is a co-chaperone of hsp90 which regulates
glucocorticoid receptor (GR) sensitivity. When it is bound to the receptor complex, cortisol …
glucocorticoid receptor (GR) sensitivity. When it is bound to the receptor complex, cortisol …
Biomarkers of suicide attempt behavior: towards a biological model of risk
K Sudol, JJ Mann - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review The rising suicide rate in the USA will not be reversed without
improved risk assessment and prevention practices. To date, the best method for clinicians …
improved risk assessment and prevention practices. To date, the best method for clinicians …
The molecular bases of the suicidal brain
G Turecki - Nature Reviews Neuroscience, 2014 - nature.com
Suicide ranks among the leading causes of death around the world and takes a heavy
emotional and public health toll on most societies. Both distal and proximal factors contribute …
emotional and public health toll on most societies. Both distal and proximal factors contribute …
Childhood trauma in mood disorders: neurobiological mechanisms and implications for treatment
P Jaworska-Andryszewska, JK Rybakowski - Pharmacological reports, 2019 - Elsevier
A contemporary model for the pathogenesis of mood disorders (bipolar and depressive
disorders) involves gene-environmental interaction, with genetic predisposition, epigenetic …
disorders) involves gene-environmental interaction, with genetic predisposition, epigenetic …
Hypothalamic–pituitary–adrenal axis and stress
C Leistner, A Menke - Handbook of clinical neurology, 2020 - Elsevier
Stress is associated with the onset of several stress-related mental disorders that occur more
frequently in women than in men, such as major depression or posttraumatic stress disorder …
frequently in women than in men, such as major depression or posttraumatic stress disorder …
Personalized medicine in psychiatry: problems and promises
U Ozomaro, C Wahlestedt, CB Nemeroff - BMC medicine, 2013 - Springer
The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …
physiologic characteristics play a significant role in both disease vulnerability and in …
Neuropathology of suicide: recent findings and future directions
Suicide is a major public health concern and a leading cause of death in most societies.
Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It …
Suicidal behaviour is complex and heterogeneous, likely resulting from several causes. It …