Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

Inorganic polyphosphates (polyPs) and inositol pyrophosphates (PP‐InsPs) form important
stores of inorganic phosphate and can act as energy metabolites and signaling molecules …

The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-
InsPs) is a daunting challenge due to the large number of possible isomers, the absence of …

Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that
are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate …

Although many prokaryotes have glycolysis alternatives, it's considered as the only energy-
generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid …

Phosphate's central role in most biochemical reactions in a living organism requires
carefully maintained homeostasis. Although phosphate homeostasis in mammals has long …

Technical challenges have to date prevented a complete profiling of the levels of myo-
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …

Homeostasis of cellular fluxes of inorganic phosphate (Pi) supervises its structural roles in
bones and teeth, its pervasive regulation of cellular metabolism, and its functionalization of …

Reversible protein phosphorylation is a central signaling mechanism in eukaryotes.
Although mass-spectrometry-based phosphoproteomics has become routine, identification …

Obesity and obesity-induced metabolic dysfunctions are significant risk factors for
nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic …