Review and recommendations on deformable image registration uncertainties for radiotherapy applications

L Nenoff, F Amstutz, M Murr… - Physics in Medicine …, 2023 - iopscience.iop.org
Deformable image registration (DIR) is a versatile tool used in many applications in
radiotherapy (RT). DIR algorithms have been implemented in many commercial treatment …

[HTML][HTML] Large anatomical changes in head-and-neck cancers–A dosimetric comparison of online and offline adaptive proton therapy

M Bobić, A Lalonde, KP Nesteruk, H Lee… - Clinical and …, 2023 - Elsevier
Purpose This work evaluates an online adaptive (OA) workflow for head-and-neck (H&N)
intensity-modulated proton therapy (IMPT) and compares it with full offline replanning (FOR) …

Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and …

A Lalonde, M Bobić, GC Sharp… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. To evaluate the impact of setup uncertainty reduction (SUR) and adaptation to
geometrical changes (AGC) on normal tissue complication probability (NTCP) when using …

An operator-independent quality assurance system for automatically generated structure sets

A Bookbinder, M Bobić, GC Sharp… - Physics in Medicine & …, 2024 - iopscience.iop.org
Objective. This study describes geometry-based and intensity-based tools for quality
assurance (QA) of automatically generated structures for online adaptive radiotherapy, and …

Comparing Predicted Toxicities between Hypofractionated Proton and Photon Radiotherapy of Liver Cancer Patients with Different Adaptive Schemes

L Nenoff, A Sudhyadhom, J Lau, GC Sharp… - Cancers, 2023 - mdpi.com
Simple Summary The availability of high-quality image guidance and fully integrated online
adaptation now allows for an efficient online adaptation for photon treatments. Since proton …

Robust optimization strategies for contour uncertainties in online adaptive radiation therapy

A Smolders, I Bengtsson, A Forsgren… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective. Online adaptive radiation therapy requires fast and automated contouring of daily
scans for treatment plan re-optimization. However, automated contouring is imperfect and …

The partial adaptation strategy for online‐adaptive proton therapy: A proof of concept study in head and neck cancer patients

V Gambetta, A Fredriksson, S Menkel… - Medical …, 2024 - Wiley Online Library
Background The accuracy of intensity‐modulated proton therapy (IMPT) is greatly affected
by anatomy variations that might occur during the treatment course. Online plan adaptations …

A retrospective study on the investigation of potential clinical benefits of online adaptive proton therapy for head and neck cancer

CW Chang, D Bohannon, Z Tian, Y Wang… - arXiv preprint arXiv …, 2022 - arxiv.org
Online adaptive proton therapy (APT) is an ideal solution theoretically, which however is
challenging to proton clinics. Although multiple groups have been endeavoring to develop …

[PDF][PDF] Implementation of probabilistic robust optimization with contour propagation uncertainty in adaptive radiotherapy

C Gaban, E Sterpin - dial.uclouvain.be
Background: Radiotherapy aims to effectively target tumor volumes with adequate doses
while preserving nearby healthy cells. It is challenged by the dynamic nature of patient …