The mechanistic influences of dopamine (DA) signaling and impact on motor function are
nearly always interpreted from changes in nigrostriatal neuron terminals in striatum. This is a …

Innovative therapeutic strategies are urgently needed for Parkinson's disease due to limited
efficacy of current treatments and a weak therapeutic pipeline. In this forum article, we …

Parkinson's Disease (PD) is characterized by the loss of dopaminergic neurons, with
ferroptosis playing a significant role. Salidroside (SAL) has shown neuroprotective potential …

Parkinson's disease (PD) rodent models provide insight into the relationship between
nigrostriatal dopamine (DA) signaling and locomotor function. Although toxin-based rat …

Cognitive decline in Parkinson's disease (PD) is a critical premotor sign that may occur in
approximately 40% of PD patients up to 10 years prior to clinical recognition and diagnosis …

Alleviation of motor impairment by aerobic exercise (AE) in Parkinson's disease (PD)
patients points to activation of neurobiological mechanisms that may be targetable by …

Background Dopaminergic neurons from the substantia nigra pars compacta (SNc) have a
higher susceptibility to aging-related degeneration, compared to midbrain dopaminergic …

Parkinson's disease (PD) is a neurodegeneration disease with α-synuclein accumulated in
the substantia nigra pars compacta (SNpc) and most of the dopaminergic neurons are lost in …

Understanding the intricate role of dopamine D1–D5 receptors is pivotal in addressing the
challenges posed by the aging global population, as well as by social stress and advancing …

The mechanistic influences of dopamine (DA) signaling and impact on motor function is
nearly always interpreted from changes in nigrostriatal neuron terminals in striatum. This is a …