Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …

B cell lymphomas are cancers that arise from cells that depend on numerous highly
orchestrated interactions with immune and stromal cells in the course of normal …

The scarcity of malignant Hodgkin and Reed–Sternberg cells hampers tissue-based
comprehensive genomic profiling of classic Hodgkin lymphoma (cHL). By contrast, liquid …

Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that
induce the differentiation of B cells into plasma cells and memory cells. They are found …

Allergic disease represents a significant global health burden, and disease incidence
continues to rise in urban areas of the world. As such, a better understanding of the basic …

The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in
germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous …

The hallmark t (14; 18)(q32; q21) in follicular lymphoma (FL) results in constitutive
overexpression of the BCL2 protein, allowing B cells to abrogate the default germinal center …

Background Patients with follicular lymphoma have heterogeneous outcomes. Predictor
models to distinguish, at diagnosis, between patients at high and low risk of progression are …

Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells
undergo somatic mutation and selection and eventual differentiation into memory B cells or …

Most adult B cell lymphomas originate from germinal center (GC) B cells, but it is unclear to
what extent B cells in overt lymphoma retain the functional dynamics of GC B cells or are …