Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases

L Wang, J Li, L Di - Medicinal Research Reviews, 2022 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

Muscle wasting and aging: experimental models, fatty infiltrations, and prevention

T Brioche, AF Pagano, G Py, A Chopard - Molecular Aspects of Medicine, 2016 - Elsevier
Identification of cost-effective interventions to maintain muscle mass, muscle strength, and
physical performance during muscle wasting and aging is an important public health …

Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation

V Marion, C Stoetzel, D Schlicht… - Proceedings of the …, 2009 - National Acad Sciences
Bardet-Biedl syndrome (BBS) is an inherited ciliopathy generally associated with severe
obesity, but the underlying mechanism remains hypothetical and is generally proposed to be …

Activin a plays a critical role in proliferation and differentiation of human adipose progenitors

LE Zaragosi, B Wdziekonski, P Villageois… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Growth of white adipose tissue takes place in normal development and in
obesity. A pool of adipose progenitors is responsible for the formation of new adipocytes and …

Multi-lineage differentiation of mesenchymal stem cells–To Wnt, or not Wnt

M Visweswaran, S Pohl, F Arfuso, P Newsholme… - The international journal …, 2015 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent precursor cells originating from several
adult connective tissues. MSCs possess the ability to self-renew and differentiate into …

SPARC inhibits adipogenesis by its enhancement of β-catenin signaling

J Nie, EH Sage - Journal of Biological Chemistry, 2009 - ASBMB
SPARC (secreted protein acidic and rich in cysteine) modulates interactions between cells
and extracellular matrix and is enriched in white adipose tissue. We have reported that …

[HTML][HTML] Wnt signaling behaves as a “master regulator” in the osteogenic and adipogenic commitment of human amniotic fluid mesenchymal stem cells

I D'Alimonte, A Lannutti, C Pipino, P Di Tomo… - Stem Cell Reviews and …, 2013 - Springer
Human amniotic fluid mesenchymal stem cells (huAFMSCs) are emerging as a promising
therapeutic option in regenerative medicine. Here, we characterized huAFMSC phenotype …

Circadian clock genes modulate human bone marrow mesenchymal stem cell differentiation, migration and cell cycle

H Boucher, V Vanneaux, T Domet, A Parouchev… - PLoS …, 2016 - journals.plos.org
Many of the components that regulate the circadian clock have been identified in organisms
and humans. The influence of circadian rhythm (CR) on the regulation of stem cells biology …

High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage

NK Satija, D Sharma, F Afrin, RP Tripathi… - PloS one, 2013 - journals.plos.org
Human mesenchymal stem cells (hMSCs) present in the bone marrow are the precursors of
osteoblasts, chondrocytes and adipocytes, and hold tremendous potential for …

Metabolic contributions of Wnt signaling: more than controlling flight

F Abou Azar, GE Lim - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
The canonical Wnt signaling pathway is ubiquitous throughout the body and influences a
diverse array of physiological processes. Following the initial discovery of the Wnt signaling …