The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …

Sex-specific gonadal development starts with formation of the bipotential gonad, which then
differentiates into either a mature testis or an ovary. This process is dependent on activation …

Mammalian sexual development commences when fetal bipotential progenitor cells adopt
male Sertoli (in XY) or female granulosa (in XX) gonadal cell fates. Differentiation of these …

Background MicroRNAs (miRNA) play a key role in the regulation of gene expression
through the translational suppression and control of post-transcriptional modifications. Aim …

The body of knowledge surrounding reproductive development spans the fields of genetics,
anatomy, physiology and biomedicine, to build a comprehensive understanding of the later …

Non-coding RNAs (ncRNAs) are a group of RNAs that do not encode functional proteins,
including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), PIWI-interacting RNAs …

Hyriopsis cumingii is an important species for freshwater pearl cultivation in China. In terms
of pearl production, males have larger pearls and better glossiness than females, but there …

Although sex determination and differentiation are key developmental processes in animals,
the involvement of non-coding RNA in the regulation of this process is still not clarified. The …

MicroRNAs (miRNAs) play an important role in gonadal development and differentiation in
fish. However, understanding of the mechanism of this process is hindered by our poor …