The endocannabinoid system (ECS) is an important brain modulatory network. ECS
regulates brain homeostasis throughout development, from progenitor fate decision to neuro …

There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis,
prognosis, and treatment of different tumor types. Described as a prognostic marker for many …

Ultraviolet (UV) radiation is a major cause of photoaging that can induce DNA damage,
oxidative stress, and cellular aging. Metformin (MF) can repair DNA damage, scavenge …

Pancreatic cancer is one of the most serious health issues in developed and developing
countries, with a 5‐year overall survival rate currently< 9%. Patients typically present with …

Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and invasive type of
pancreatic cancer (PCa) and is expected to be the second most common cause of cancer …

Breast cancer (BC) is the most common malignancy in women worldwide. While the main
systemic treatment option is anthracycline-containing chemotherapy, chemoresistance …

Cellular senescence is a state of proliferative arrest, and the development of carcinoma can
be suppressed by conferring tumor cell senescence. Recently, we found that carnitine …

Abstract Carnitine palmitoyltransferase 1C (CPT1C) is an enzyme that regulates tumor cell
proliferation and metabolism by modulating mitochondrial function and lipid metabolism …

Background: Precision-Cut Liver Slices (PCLS) are an ex vivo culture model developed to
study hepatic drug metabolism. One of the main benefits of this model is that it retains the …

Carnitine palmitoyl transferase 1 (CPT1) are enzymes that catalyze the conversion of long-
chain acyl-CoA to acyl-carnitines, to transport long-chain fatty acids across intracellular …