COVID-19: pulmonary and extra pulmonary manifestations

IH Elrobaa, KJ New - Frontiers in public health, 2021 - frontiersin.org
Introduction: The coronavirus disease-2019 (COVID-19) pandemic has been the most
significant event in 2020, with~ 86.8 million cases and 1.88 million deaths worldwide. It is a …

Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike

AR Mehdipour, G Hummer - Proceedings of the National …, 2021 - National Acad Sciences
Binding of the spike protein of SARS-CoV-2 to the human angiotensin-converting enzyme 2
(ACE2) receptor triggers translocation of the virus into cells. Both the ACE2 receptor and the …

ACE2: the key molecule for understanding the pathophysiology of severe and critical conditions of COVID-19: demon or angel?

L Xiao, H Sakagami, N Miwa - Viruses, 2020 - mdpi.com
Recently, the SARS-CoV-2 induced disease COVID-19 has spread all over the world. Nearly
20% of the patients have severe or critical conditions. SARS-CoV-2 exploits ACE2 for host …

Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID‐19—Mechanisms and Therapeutic Targets

A Fodor, B Tiperciuc, C Login… - Oxidative medicine …, 2021 - Wiley Online Library
The outbreak of the COVID‐19 pandemic represents an ongoing healthcare emergency
responsible for more than 3.4 million deaths worldwide. COVID‐19 is the disease caused by …

Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: a case-control study

M Abrishami, Z Emamverdian, N Shoeibi… - Canadian Journal of …, 2021 - Elsevier
Objective To quantify the density of the macular microvasculature and the area of the foveal
avascular zone (FAZ) in patients recovered from coronavirus disease 2019 (COVID-19) …

The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor-and angiotensin II receptor blocker-based cardiovascular …

A Albini, G Di Guardo, DMC Noonan… - Internal and emergency …, 2020 - Springer
SARS-CoV-2 is characterized by a spike protein allowing viral binding to the angiotensin-
converting enzyme (ACE)-2, which acts as a viral receptor and is expressed on the surface …

Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications

N Banu, SS Panikar, LR Leal, AR Leal - Life sciences, 2020 - Elsevier
In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international
scientific community has joined forces to develop effective treatment strategies. The …

[HTML][HTML] COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches

F Moccia, A Gerbino, V Lionetti, M Miragoli… - Geroscience, 2020 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells following
binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 …

Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress

R Zaman, H Hamidzada, C Kantores, A Wong, SA Dick… - Immunity, 2021 - cell.com
Hypertension affects one-third of the world's population, leading to cardiac dysfunction that
is modulated by resident and recruited immune cells. Cardiomyocyte growth and increased …