Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …

Chimeric antigen receptor (CAR) T cell therapy relies on the ex vivo manipulation of patient
T cells to create potent, cancer-targeting therapies, shown to be capable of inducing …

In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …

The treatment of cancer patients with autologous T cells expressing a chimeric antigen
receptor (CAR) is one of the most promising adoptive cellular therapy approaches …

Adoptive T cell transfer for cancer and chronic infection is an emerging field that shows
promise in recent trials. Synthetic-biology-based engineering of T lymphocytes to express …

Chimeric antigen receptor T-cell (CAR-T) therapy has been prosperous in the treatment of
patients with various types of relapsed/refractory (R/R) B-cell malignancies including diffuse …

Induction treatments for acute myeloid leukemia (AML) have remained largely unchanged
for nearly 50 years, and AML remains a disease of poor prognosis. Allogeneic …

Improved outcomes for patients with cancer hinge on the development of new targeted
therapies with acceptable short-term and long-term toxicity. Progress in basic, preclinical …

The study of RNA has continually emphasized the structural and functional versatility of RNA
molecules. This versatility has inspired translational and clinical researchers to explore the …