Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

The oral microbiome has been implicated in a growing number of diseases; however,
determinants of the oral microbiome and their roles remain elusive. Here, we investigated …

Although recent studies have revealed the association between the human microbiome
especially gut microbiota and longevity, their causality remains unclear. Here, we assess the …

Background Lifestyle and longevity genes have different and important roles in the human
lifespan; however, the association between a healthy lifestyle in late-life and life expectancy …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Diverse individuals age at different rates and display variable susceptibilities to tissue aging,
functional decline and aging-related diseases. Centenarians, exemplifying extreme …

The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

Background: Both leisure activities and the ε4 allele of the apolipoprotein E (APOE ε4) have
been shown to affect cognitive health. We aimed to determine whether engagement in …

我国已快速进入老龄化社会, 人口老龄化及老年人群的健康问题日益突出,
长寿老人作为“健康老人模板”, 对其开展健康相关的流行病学研究, 建设健康老龄社会有重要的 …