Regulation of protein binding through autoinhibition commonly occurs via interactions
involving intrinsically disordered regions (IDRs). These intramolecular interactions can …

The MCM motor of the replicative helicase is loaded onto origin DNA as an inactive double
hexamer before replication initiation. Recruitment of activators GINS and Cdc45 upon S …

Cryo-sample preparation is a vital step in the process of obtaining high-resolution structures
of macromolecules by using the single-particle cryo–electron microscopy (cryo-EM) method; …

In eukaryotes, DNA replication initiation requires assembly and activation of the
minichromosome maintenance (MCM) 2–7 double hexamer (DH) to melt origin DNA …

The replisome that replicates the eukaryotic genome consists of at least three engines: the
Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and …

Some DNA helicases play central and specific roles in genome maintenance and plasticity
through their branch migration activity in different pathways of homologous recombination …

Accurate and integral cellular DNA replication is modulated by multiple replication‐
associated proteins, which is fundamental to preserve genome stability. Furthermore …

Minichromosome maintenance complex component 6 (MCM6), a member of the MCM
family, plays a pivotal role in DNA replication initiation and genome duplication of …

Simple Summary To ensure the maintenance of genetic stability prior to cell division a cell's
complement of chromosomes must be duplicated. This requires not only the replication of …

The cryo-electron microscopy (cryoEM) method has enabled high-resolution structure
determination of numerous biomolecules and complexes. Nevertheless, cryoEM sample …