[HTML][HTML] Parkinson's disease: mechanisms and models

W Dauer, S Przedborski - Neuron, 2003 - cell.com
Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …

[HTML][HTML] Programmed cell death in diabetic nephropathy: a review of apoptosis, autophagy, and necroptosis

NS Erekat - Medical Science Monitor: International Medical Journal …, 2022 - ncbi.nlm.nih.gov
Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal
glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension …

Apoptosis and its Role in Parkinson's Disease

NS Erekat - Exon Publications, 2018 - exonpublications.com
Parkinson's disease is one of the most common neurodegenerative diseases in the elderly.
The motor symptoms occur predominantly due to substantial dopamine depletion, caused by …

Semaglutide is neuroprotective and reduces α-synuclein levels in the chronic MPTP mouse model of Parkinson's disease

L Zhang, LY Zhang, L Li… - Journal of Parkinson's …, 2019 - content.iospress.com
Parkinson's disease (PD) is a progressive neurological motor control disorder. A key feature
is the loss of midbrain dopaminergic neurons and the accumulation of aggregated alpha …

What and how can physical activity prevention function on Parkinson's disease?

B Fan, R Jabeen, B Bo, C Guo, M Han… - Oxidative medicine …, 2020 - Wiley Online Library
Aim. This study was aimed at investigating the effects and molecular mechanisms of
physical activity intervention on Parkinson's disease (PD) and providing theoretical …

Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice

N Peker, M Sharma, R Kambadur - npj Parkinson's Disease, 2022 - nature.com
Parkinson's Disease (PD) is a chronic and progressive neurodegenerative disease
manifesting itself with tremors, muscle stiffness, bradykinesia, dementia, and depression …

S1P signalling axis is necessary for adiponectin-directed regulation of electrophysiological properties and oxidative metabolism in C2C12 myotubes

C Bernacchioni, R Squecco, T Gamberi, V Ghini… - Cells, 2022 - mdpi.com
Background: Adiponectin (Adn), released by adipocytes and other cell types such as
skeletal muscle, has insulin-sensitizing and anti-inflammatory properties. Sphingosine 1 …

[HTML][HTML] Respiratory function and dysfunction in Parkinson-type neurodegeneration

M Pokusa, D Hajduchova, T Buday… - Physiological …, 2020 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is most commonly manifested by the presence of motor symptoms.
However, non-motor symptoms occur several years before the onset of motor symptoms …

Cerebellar Purkinje cells die by apoptosis in the shaker mutant rat

NS Erekat - Brain research, 2017 - Elsevier
Abstract Cerebellar Purkinje cells (PCs) die in humans leading to a variety of diseases
including ataxia and essential tremor. The etiology underlying PC death is poorly …

[HTML][HTML] Interleukin-1 beta and tumor necrosis factor alpha upregulation and nuclear factor kappa B activation in skeletal muscle from a mouse model of chronic …

NS Erekat, MD Al-Jarrah - Medical science monitor: international …, 2018 - ncbi.nlm.nih.gov
Background Skeletal muscle atrophy has been reported in patients with Parkinson disease
(PD). The purpose of this study was to examine the potential implication of interleukin 1 beta …