Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora

H Sadrekarimi, ZR Gardanova, M Bakhshesh… - Journal of translational …, 2022 - Springer
In recent years, there has been a greater emphasis on the impact of microbial populations
inhabiting the gastrointestinal tract on human health and disease. According to the …

MiRNA-based therapeutic intervention of cancer

S Naidu, P Magee, M Garofalo - Journal of hematology & oncology, 2015 - Springer
MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting
protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus …

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

E Rodriguez, K Boelaars, K Brown… - Nature …, 2021 - nature.com
Abstract Changes in glycosylation during tumour progression are a key hallmark of cancer.
One of the glycan moieties generally overexpressed in cancer are sialic acids, which can …

MicroRNA-92a-1–5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia

T Li, H Guo, H Li, Y Jiang, K Zhuang, C Lei, J Wu… - Gut, 2019 - gut.bmj.com
Background and aims Gastric intestinal metaplasia (IM) is common in the gastric epithelium
of patients with chronic atrophic gastritis. CDX2 activation in IM is driven by reflux of bile …

The SWI/SNF complex subunit genes: Their functions, variations, and links to risk and survival outcomes in human cancers

S Savas, G Skardasi - Critical reviews in oncology/hematology, 2018 - Elsevier
SWI/SNF is a multiprotein complex essential for regulation of eukaryotic gene expression. In
this article, we review the function and characteristics of this complex and its subunits in …

[HTML][HTML] LncRNA LINC00173 enhances triple-negative breast cancer progression by suppressing miR-490-3p expression

H Fan, J Yuan, X Li, Y Ma, X Wang, B Xu, X Li - Biomedicine & …, 2020 - Elsevier
Long non-coding RNA (lncRNA) LINC00173 has been previously shown to promote
chemoresistance and progression of small-cell lung cancer. Herein, we examine the clinical …

Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis

AKH Loe, L Zhu, TH Kim - Experimental & molecular medicine, 2023 - nature.com
Gastric cancer (GC) is one of the most common and deadly cancers in the world. It is a
multifactorial disease highly influenced by environmental factors, which include radiation …

MicroRNA-490-3P targets CDK1 and inhibits ovarian epithelial carcinoma tumorigenesis and progression

S Chen, X Chen, YL Xiu, KX Sun, Y Zhao - Cancer letters, 2015 - Elsevier
Abstract The expression of microRNA-490-3P has been reported to regulate hepatocellular
carcinoma cell proliferation, migration and invasion, and its overexpression significantly …

Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer

NB Ghate, S Kim, Y Shin, J Kim, M Doche… - Nature …, 2023 - nature.com
Our recent work has shown that DCAF1 (also known as VprBP) is overexpressed in colon
cancer and phosphorylates histone H2AT120 to drive epigenetic gene inactivation and …

CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression

H Wang, W Chen, M Jin, L Hou, X Chen, R Zhang… - Molecular cancer, 2018 - Springer
Abstract Background Non-coding RNAs (ncRNAs) have been reported to participate in
tumor progression by regulating gene expression. Previous studies showed that protein …