The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being …

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is an extremely abundant protein in the brain
where, remarkably, it is estimated to make up 1–5% of total neuronal protein. Although it …

Oxidative stress is involved in various and numerous pathological states including several
age-related neurodegenerative diseases. Peroxidation of the membrane lipid bilayer is one …

Oxidative stress occurs in a variety of disease settings and is strongly linked to the
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …

Although oxidants clearly possess the capacity to behave in a random and destructive
fashion, growing evidence suggests that in many instances the production of reactive …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder
characterized by death of motor neurons leading to muscle wasting, paralysis, and death …

Oxidative stress has a significant impact on the development and progression of common
human pathologies, including cancer, diabetes, hypertension and neurodegenerative …

Study design: Literature review. Objectives: Spinal cord injury (SCI) remains a major public
health issue in developed countries as well as worldwide. The pathophysiology of SCI is …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

The cause (s) of amyotrophic lateral sclerosis (ALS) is not fully understood in the vast
majority of cases and the mechanisms involved in motor neuron degeneration are multi …