Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition

DL Simmons, RM Botting, T Hla - Pharmacological reviews, 2004 - ASPET
Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most highly utilized
classes of pharmaceutical agents in medicine. All NSAIDs act through inhibiting …

Anti-inflammatory actions of glucocorticoids: molecular mechanisms

PJ Barnes - Clinical science, 1998 - portlandpress.com
1. Glucocorticoids are widely used for the suppression of inflammation in chronic
inflammatory diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease …

[HTML][HTML] High levels of eicosanoids and docosanoids in the lungs of intubated COVID‐19 patients

AS Archambault, Y Zaid, V Rakotoarivelo… - The FASEB …, 2021 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 is responsible for coronavirus disease
2019 (COVID‐19). While COVID‐19 is often benign, a subset of patients develops severe …

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

TD Warner, F Giuliano, I Vojnovic… - Proceedings of the …, 1999 - National Acad Sciences
The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with
inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with …

Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

PJ Jakobsson, S Thorén… - Proceedings of the …, 1999 - National Acad Sciences
Human prostaglandin (PG) E synthase (EC 5.3. 99.3) is a member of a recently recognized
protein superfamily consisting of membrane associated proteins involved in eicosanoid and …

[HTML][HTML] Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

R Langenbach, SG Morham, HF Tiano, CD Loftin… - Cell, 1995 - cell.com
Abstract Cyclooxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin
biosynthesis and the target enzymes for the widely used nonsteroidal anti-inflammatory …

Molecular mechanisms of glucocorticoid action: what is important?

R Newton - Thorax, 2000 - thorax.bmj.com
Inflammatory diseases such as asthma and rheumatoid arthritis are characterised at the
molecular level by chronically increased expression of multiple cytokines, chemokines …

Potential mechanisms of cancer chemoprevention by anthocyanins

DX Hou - Current molecular medicine, 2003 - ingentaconnect.com
Anthocyanins are the chemical components that give the intense color to many fruits and
vegetables, such as blueberries, red cabbages and purple sweet potatoes. Epidemiological …

Inflammatory mediators of asthma: an update

PJ Barnes, KF Chung, CP Page - Pharmacological reviews, 1998 - ASPET
Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

[PDF][PDF] Anti-inflammatory and side effects of cyclo-oxygenase inhibitors

H Suleyman, B Demircan, Y Karagoz - Pharmacological reports, 2007 - academia.edu
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs in
inflammatory diseases, since they are effective in management of pain, fever, redness …