Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Long known as terminal degradation stations, lysosomes have emerged as sophisticated
signalling centres that govern cell growth, division and differentiation. Lysosomes interface …

The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that
controls the cellular response to environmental cues by exerting its kinase activity on …

The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell
growth and metabolism through the modulation of protein and lipid synthesis, lysosome …

Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival,
metabolism, and immunity. mTOR is usually assembled into several complexes such as …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling hub integrates multiple
environmental cues to modulate cell growth and metabolism. Over the past decade …

The mechanistic target of rapamycin (mTOR) signaling pathway coordinates environmental
and intracellular cues to control eukaryotic cell growth. As a pivot point between anabolic …

Amino acid availability controls mTORC1 activity via a heterodimeric Rag GTPase complex
that functions as a scaffold at the lysosomal surface, bringing together mTORC1 with its …

Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …