[HTML][HTML] Machine learning techniques for personalised medicine approaches in immune-mediated chronic inflammatory diseases: applications and challenges

J Peng, EC Jury, P Dönnes, C Ciurtin - Frontiers in pharmacology, 2021 - frontiersin.org
In the past decade, the emergence of machine learning (ML) applications has led to
significant advances towards implementation of personalised medicine approaches for …

Predictors of primary response to biologic treatment [anti-TNF, vedolizumab, and ustekinumab] in patients with inflammatory bowel disease: from basic science to …

JP Gisbert, M Chaparro - Journal of Crohn's and Colitis, 2020 - academic.oup.com
Background Inflammatory bowel diseases [IBD]―ulcerative colitis and Crohn's disease―are
commonly treated with biologic drugs. However, only approximately two-thirds of patients …

[HTML][HTML] Personalizing treatment in IBD: hype or reality in 2020? Can we predict response to anti-TNF?

R Atreya, MF Neurath, B Siegmund - Frontiers in medicine, 2020 - frontiersin.org
The advent of anti-TNF agents as the first approved targeted therapy in the treatment of
inflammatory bowel disease (IBD) patients has made a major impact on our existing …

Genetics and epigenetics of IBD

V Annese - Pharmacological research, 2020 - Elsevier
Inflammatory bowel diseases (IBD) are chronic intermittent inflammatory disorders of the
gastrointestinal tract of unknown etiology but a clear genetic predisposition. Prompted by the …

[HTML][HTML] Evaluation of anti-TNF therapeutic response in patients with inflammatory bowel disease: Current and novel biomarkers

G Cui, Q Fan, Z Li, R Goll, J Florholmen - EBioMedicine, 2021 - thelancet.com
Neutralizing tumour necrosis factor (TNF) antibodies have been widely used to treat
inflammatory bowel disease (IBD) in the clinical practice. In this review, the principal …

Challenges in IBD research: precision medicine

LA Denson, M Curran, DPB McGovern… - Inflammatory bowel …, 2019 - academic.oup.com
Precision medicine is part of five focus areas of the Challenges in IBD research document,
which also includes preclinical human IBD mechanisms, environmental triggers, novel …

[HTML][HTML] Olive oil polyphenols reduce oxysterols-induced redox imbalance and pro-inflammatory response in intestinal cells

G Serra, A Incani, G Serreli, L Porru, MP Melis… - Redox biology, 2018 - Elsevier
Dietary habits may strongly influence intestinal homeostasis. Oxysterols, the oxidized
products of cholesterol present in cholesterol-containing foodstuffs, have been shown to …

[HTML][HTML] Systematic review and meta-analysis: pharmacogenetics of anti-TNF treatment response in rheumatoid arthritis

S Bek, AB Bojesen, JV Nielsen, J Sode… - The …, 2017 - nature.com
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects~ 1% of the
Caucasian population. Over the last decades, the availability of biological drugs targeting …

Precision medicine and drug optimization in adult inflammatory bowel disease patients

S Vieujean, E Louis - Therapeutic Advances in …, 2023 - journals.sagepub.com
Inflammatory bowel diseases (IBD) encompass two main entities including ulcerative colitis
and Crohn's disease. Although having a common global pathophysiological mechanism …

[HTML][HTML] Genetic studies of inflammatory bowel disease-focusing on Asian patients

SC Park, YT Jeen - Cells, 2019 - mdpi.com
The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however,
increased and persistent intestinal inflammation, due to inappropriate immune responses …