Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …

Ribonucleases (RNases) are mediators in most reactions of RNA metabolism. In recent
years, there has been a surge of new information about RNases and the roles they play in …

Conspectus Nanotechnology's central goal involves the direct control of matter at the
molecular nanometer scale to build nanofactories, nanomachines, and other devices for …

Identifying relationships between function, amino acid sequence, and protein structure
represents a major challenge. In this study, we propose a bioinformatics approach that …

Although various functions of RNA are carried out in conjunction with proteins, some
catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little …

Ribonuclease (RNase) P is the universal ribozyme responsible for 5′-end tRNA
processing. We report the crystal structure of the Thermotoga maritima RNase P …

Programmed ribosomal frameshifting (PRF) is one of the multiple translational recoding
processes that fundamentally alters triplet decoding of the messenger RNA by the …

Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of
only two known RNA-based enzymes found in all three domains of life. The RNA component …

Abstract Ribonuclease P (RNase P) is a ubiquitous endonuclease that catalyses the
maturation of the 5′ end of transfer RNA (tRNA). Although it carries out a biochemically …

Ribonuclease (RNase) P is a ubiquitous ribozyme that cleaves the 5′ leader from
precursor tRNAs. Here, we report cryo-electron microscopy structures of the human nuclear …