Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the
pathophysiology of hypertension and organ injury has changed to a major emphasis on the …

An increasing volume of experimental data indicates that the adventitial fibroblast, in both
the pulmonary and systemic circulations, is a critical regulator of vascular wall function in …

Lacunar infarcts and “hypertensive” primary intracerebral hemorrhages, collectively often
referred to as hypertensive small vessel strokes, constitute about one third of all strokes …

Cerebral small vessel disease (SVD) is a major cause of stroke and dementia.
Pathologically, three lesions are seen: small vessel arteriopathy, lacunar infarction, and …

destruct the inhibitors of proteases that are capable of proteolytically activating prorenin after
restoration of pH. Nonproteolytically activated prorenin is enzymatically fully active and can …

Since the term “lacune” was adopted in the 1800s to describe infarctions from cerebral small
vessels, their underlying pathophysiological basis remained obscure until the 1960s when …

The ability to engineer the mouse genome has profoundly transformed biomedical research.
During the last decade, conventional transgenic and gene knockout technologies have …

Objective Mannose 6-phosphate receptors (M6PR) bind both renin and prorenin, and such
binding contributes to renin/prorenin clearance but not to angiotensin generation. Here, we …

A rapidly emerging concept is that the vascular adventitia acts as a biological processing
center for the retrieval, integration, storage, and release of key regulators of vessel wall …