Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory
Since its development about 40 years ago (1981–2021), Morris water maze has turned into
a very popular tool for assessing spatial learning and memory. Its many advantages have …
a very popular tool for assessing spatial learning and memory. Its many advantages have …
Assessing spatial learning and memory in rodents
CV Vorhees, MT Williams - ILAR journal, 2014 - academic.oup.com
Maneuvering safely through the environment is central to survival of almost all species. The
ability to do this depends on learning and remembering locations. This capacity is encoded …
ability to do this depends on learning and remembering locations. This capacity is encoded …
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
Pathological aggregation of tau is a hallmark of Alzheimer's disease and related
tauopathies. We have previously shown that the deficiency of the microglial fractalkine …
tauopathies. We have previously shown that the deficiency of the microglial fractalkine …
Pattern separation in the hippocampus
The ability to discriminate among similar experiences is a crucial feature of episodic
memory. This ability has long been hypothesized to require the hippocampus, and …
memory. This ability has long been hypothesized to require the hippocampus, and …
Morris water maze: procedures for assessing spatial and related forms of learning and memory
CV Vorhees, MT Williams - Nature protocols, 2006 - nature.com
The Morris water maze (MWM) is a test of spatial learning for rodents that relies on distal
cues to navigate from start locations around the perimeter of an open swimming arena to …
cues to navigate from start locations around the perimeter of an open swimming arena to …
Applications of the Morris water maze in the study of learning and memory
R D'Hooge, PP De Deyn - Brain research reviews, 2001 - Elsevier
The Morris water maze (MWM) was described 20 years ago as a device to investigate
spatial learning and memory in laboratory rats. In the meanwhile, it has become one of the …
spatial learning and memory in laboratory rats. In the meanwhile, it has become one of the …
[PDF][PDF] A specific amyloid-β protein assembly in the brain impairs memory.
Memory function often declines with age1, and is believed to deteriorate initially because of
changes in synaptic function rather than loss of neurons2. Some individuals then go on to …
changes in synaptic function rather than loss of neurons2. Some individuals then go on to …
Relationships between diet-related changes in the gut microbiome and cognitive flexibility
KR Magnusson, L Hauck, BM Jeffrey, V Elias… - Neuroscience, 2015 - Elsevier
Western diets are high in fat and sucrose and can influence behavior and gut microbiota.
There is growing evidence that altering the microbiome can influence the brain and …
There is growing evidence that altering the microbiome can influence the brain and …
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment
Functional magnetic resonance imaging (fMRI) studies have observed hyperactivity in the
hippocampal region in individuals with Mild Cognitive Impairment (MCI). However, the …
hippocampal region in individuals with Mild Cognitive Impairment (MCI). However, the …
Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
SSD Stone, CM Teixeira, LM DeVito… - Journal of …, 2011 - Soc Neuroscience
Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of
movement disorders and an emerging therapeutic approach for the treatment of disorders of …
movement disorders and an emerging therapeutic approach for the treatment of disorders of …