Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly
throughout the world and threaten to become untreatable. The origins of resistance are …

Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …

Mycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important
goal of tuberculosis research is to shorten the treatment to reduce the burden on patients …

The emergence of multi-and extensively drug resistant tuberculosis worldwide poses a great
threat to human health and highlight the need to discover and develop new, effective and …

The potential for the build-up of resistance to a particular antibiotic endangers its therapeutic
application over time. In recent decades, antibiotic resistance has become one of the most …

Efflux proteins are transporter molecules that actively pump out a variety of substrates,
including antibiotics, from cells to the environment. They are found in both Gram-positive …

Curcumin is the principal curcuminoid obtained from the plant Curcuma longa and has been
extensively studied for its biological and chemical properties. Curcumin displays a vast …

Tuberculosis, disease caused by Mycobacterium tuberculosis, is currently the leading cause
of death by a single infectious agent worldwide. Early, rapid and accurate identification of M …

Background In order to shorten the course of treatment and its effectiveness, it is essential to
gain an in-depth insight into the drug resistance mechanisms of Mycobacterium tuberculosis …