One of the major impediments to drug development is low aqueous solubility and thus poor
bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the …

In recent years, in situ gel delivery systems have received a great deal of attention among
pharmacists. The in situ gelation mechanism has several advantages over ointments, the …

Itraconazole is a lipophilic drug, which limits its absorption for ocular administration. This
study focused on the incorporation of itraconazole into nanocrystalline carrier system with …

The gels of cellulose and its derivatives have a broad and deep application in
pharmaceutics; however, limited attention has been paid to the influences of other additives …

Purpose Thermosensitive in situ gels have been around for decades but only a few have
been translated into ophthalmic pharmaceuticals. The aim of this study was to combine the …

The therapeutic effect of common ocular drug delivery systems is often limited because tear
fluid, protective biological barriers, and the blink reflex prevent drugs from reaching their …

The incidence of corneal fungal infections continues to be a growing concern worldwide.
Ocular delivery of anti-fungal drugs is challenging due to the anatomical and physiological …

Fungal eye infections are caused mainly by an eye injury and can result in serious eye
damage. Fluconazole (FLZ), a broad-spectrum antifungal agent, is a poorly soluble drug …

Abstract Poloxamer 407 (P407) is widely used for targeted drug-delivery because it exhibits
thermoresponsive gelation behavior near body temperature, stemming from a disorder-to …

Staphylococcus aureus (S. aureus) is the main pathogen that leads to serious ocular
infectious disorders such as endophthalmitis and keratitis. A major obstacle in managing …