[HTML][HTML] High-content CRISPR screening
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …
interrogation of gene function in a wide range of applications and species. In pooled …
[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …
9) shows the opportunity to treat a diverse array of untreated various genetic and …
CRISPR-based technologies for the manipulation of eukaryotic genomes
The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …
advances in the life sciences that have grown from the ability to edit genomes within living …
[HTML][HTML] Transformative network modeling of multi-omics data reveals detailed circuits, key regulators, and potential therapeutics for Alzheimer's disease
To identify the molecular mechanisms and novel therapeutic targets of late-onset
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …
Pooled in vitro and in vivo CRISPR-Cas9 screening identifies tumor suppressors in human colon organoids
Colorectal cancer (CRC) is characterized by prominent genetic and phenotypic
heterogeneity between patients. To facilitate high-throughput genetic testing and functional …
heterogeneity between patients. To facilitate high-throughput genetic testing and functional …
CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering
DJ Dickinson, B Goldstein - Genetics, 2016 - academic.oup.com
The advent of genome editing techniques based on the clustered regularly interspersed
short palindromic repeats (CRISPR)–Cas9 system has revolutionized research in the …
short palindromic repeats (CRISPR)–Cas9 system has revolutionized research in the …
[HTML][HTML] Computational approaches for effective CRISPR guide RNA design and evaluation
Abstract The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR-
associated (Cas) system has emerged as the main technology for gene editing. Successful …
associated (Cas) system has emerged as the main technology for gene editing. Successful …
Genome editing: A perspective on the application of CRISPR/Cas9 to study human diseases
DR Rodríguez-Rodríguez… - International …, 2019 - spandidos-publications.com
Genome editing reemerged in 2012 with the development of CRISPR/Cas9 technology,
which is a genetic manipulation tool derived from the defense system of certain bacteria …
which is a genetic manipulation tool derived from the defense system of certain bacteria …
Potential pitfalls of CRISPR/Cas9‐mediated genome editing
R Peng, G Lin, J Li - The FEBS journal, 2016 - Wiley Online Library
Recently, a novel technique named the clustered regularly interspaced short palindromic
repeat (CRISPR)/CRISPR‐associated protein (Cas) 9 system has been rapidly developed …
repeat (CRISPR)/CRISPR‐associated protein (Cas) 9 system has been rapidly developed …
Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed
biomedical research and provided entirely new models to analyze every aspect of …
biomedical research and provided entirely new models to analyze every aspect of …