Measurement of the transcriptomes of single cells has been feasible for only a few years, but
it has become an extremely popular assay. While many types of analysis can be carried out …

Single-cell data provide a means to dissect the composition of complex tissues and
specialized cellular environments. However, the analysis of such measurements is …

Single-cell RNA-seq mammalian transcriptome studies are at an early stage in uncovering
cell-to-cell variation in gene expression, transcript processing and editing, and regulatory …

Gertz, Jason et al.,“Transposease mediated construction of RNA seq libraries”, Genome
Research, 22 (1), 2012, 134-141. Isalm, et al.,“Quantitative single-cell RNA-seq with unique …

Transcriptome profiling by RNA sequencing (RNA-seq) has been widely used to
characterize cellular status, but it relies on second-strand complementary DNA (cDNA) …

DNA methylation is the most studied epigenetic modification, and altered DNA methylation
patterns have been identified in cancer and more recently also in many other complex …

Single-cell analyses have revealed a tremendous variety among cells in the abundance and
chemical composition of RNA. Much of this heterogeneity is due to alternative splicing by the …

Inheritance of non-genetic factors permits ancestral environmental history to inform the
development of subsequent generations. This form of soft inheritance has been shown in …

Cholinergic neurotransmission is impaired in Alzheimer's disease (AD), and loss of basal
forebrain cholinergic neurons is a key component of disease pathogenicity and …

In the early vertebrate embryo, cardiac progenitor/precursor cells (CPs) give rise to cardiac
structures. Better understanding their biological character is critical to understand the heart …