Optimization of metabolomic data processing using NOREVA
A typical output of a metabolomic experiment is a peak table corresponding to the intensity
of measured signals. Peak table processing, an essential procedure in metabolomics, is …
of measured signals. Peak table processing, an essential procedure in metabolomics, is …
The isoniazid paradigm of killing, resistance, and persistence in Mycobacterium tuberculosis
C Vilchèze, WR Jacobs Jr - Journal of molecular biology, 2019 - Elsevier
Isoniazid (INH) was the first synthesized drug that mediated bactericidal killing of the
bacterium Mycobacterium tuberculosis, a major clinical breakthrough. To this day, INH …
bacterium Mycobacterium tuberculosis, a major clinical breakthrough. To this day, INH …
NOREVA: enhanced normalization and evaluation of time-course and multi-class metabolomic data
Biological processes (like microbial growth & physiological response) are usually dynamic
and require the monitoring of metabolic variation at different time-points. Moreover, there is …
and require the monitoring of metabolic variation at different time-points. Moreover, there is …
Zeolitic Imidazolate Framework‐8 Triggers the Inhibition of Arginine Biosynthesis to Combat Methicillin‐Resistant Staphylococcus Aureus
The self‐preservation and intelligent survival abilities of methicillin‐resistant Staphylococcus
aureus (MRSA) result in the ineffective treatment of many antibiotics. Nano‐drug delivery …
aureus (MRSA) result in the ineffective treatment of many antibiotics. Nano‐drug delivery …
Rifampicin drug resistance and host immunity in tuberculosis: more than meets the eye
Tuberculosis (TB) is the leading cause of death due to an infectious agent, with more than
1.5 million deaths attributed to TB annually worldwide. The global dissemination of drug …
1.5 million deaths attributed to TB annually worldwide. The global dissemination of drug …
Ferrous sulfate-loaded hydrogel cures Staphylococcus aureus infection via facilitating a ferroptosis-like bacterial cell death in a mouse keratitis model
Hydrogels loaded with ampicillin, vancomycin or other antibiotics are one of the most widely
used therapeutic agents for keratitis caused by Staphylococcus aureus. However …
used therapeutic agents for keratitis caused by Staphylococcus aureus. However …
Incorporating copper-based nanosheets into an injectable self-healing hydrogel enables superb repair of infected diabetic wound
D Xie, C Hu, C Jiang, J Xia, L Ye, Y Jin, S Jiang… - Chemical Engineering …, 2023 - Elsevier
Continuous bleeding, bacterial infection, oxidative stress, and vascular damage within a
diabetic wound microenvironment necessitate the development of multifunctional dressings …
diabetic wound microenvironment necessitate the development of multifunctional dressings …
Host defense mechanisms against Mycobacterium tuberculosis
Q Chai, Z Lu, CH Liu - Cellular and Molecular Life Sciences, 2020 - Springer
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains the
leading cause of death worldwide from a single infectious pathogen. Mtb is a paradigmatic …
leading cause of death worldwide from a single infectious pathogen. Mtb is a paradigmatic …
[HTML][HTML] Reactive species and pathogen antioxidant networks during phagocytosis
L Piacenza, M Trujillo, R Radi - Journal of Experimental Medicine, 2019 - rupress.org
The generation of phagosomal cytotoxic reactive species (ie, free radicals and oxidants) by
activated macrophages and neutrophils is a crucial process for the control of intracellular …
activated macrophages and neutrophils is a crucial process for the control of intracellular …