Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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CRISPR/Cas systems for genomic modification and gene modulation
F Wu - US Patent 9,738,908, 2017 - Google Patents
The invention relates to engineered CRISPR/Cas9 systems for genomic modification and
regulation of gene expression in mammalian cells. The specification describes the design …
regulation of gene expression in mammalian cells. The specification describes the design …
Compositions and methods for modifying genomes
M Begemann, BN Gray - US Patent 9,896,696, 2018 - Google Patents
Compositions and methods for modifying genomic DNA sequences are provided. The
methods produce double-stranded breaks (DSBs) at pre-determined target sites in a …
methods produce double-stranded breaks (DSBs) at pre-determined target sites in a …
CRISPR-based genome modification and regulation
F Chen, GD Davis - US Patent 10,731,181, 2020 - Google Patents
The present invention provides RNA-guided endonucleases, which are engineered for
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
F Zhang, L Cong, RAN Fei - US Patent 10,577,630, 2020 - Google Patents
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Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence
and, together with a modifying polypeptide, provides for site-specific modification of a target …
and, together with a modifying polypeptide, provides for site-specific modification of a target …
CRISPR-related methods and compositions with governing gRNAS
F Zhang, D Palestrant, B Davidson, J Mata-Fink… - US Patent …, 2017 - Google Patents
US9834791B2 - CRISPR-related methods and compositions with governing gRNAS -
Google Patents US9834791B2 - CRISPR-related methods and compositions with …
Google Patents US9834791B2 - CRISPR-related methods and compositions with …
Compositions and methods directed to CRISPR/Cas genomic engineering systems
F Wu - US Patent 9,234,213, 2016 - Google Patents
The invention relates to engineered CRISPR/Cas9 systems for genomic modification in
mammalian cells. The present specification describes the design and testing of a polynucle …
mammalian cells. The present specification describes the design and testing of a polynucle …
Methods and compositions for sequence guiding Cas9 targeting
R Barrangou, KM Selle, AE Briner - US Patent 10,787,654, 2020 - Google Patents
US10787654B2 - Methods and compositions for sequence guiding Cas9 targeting - Google
Patents US10787654B2 - Methods and compositions for sequence guiding Cas9 targeting …
Patents US10787654B2 - Methods and compositions for sequence guiding Cas9 targeting …
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
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