Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …

The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …

Background and Purpose Sphingosine1‐phosphate (S1P) receptors mediate multiple
events including lymphocyte trafficking, cardiac function, and endothelial barrier integrity …

The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking,
endothelial development and integrity, heart rate, and vascular tone and maturation by …

Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …

The immunomodulatory drug fingolimod (FTY720, Gilenya R) was approved for oral
treatment of relapsing-remitting multiple sclerosis, due to its impressive efficacy and good …

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cellular processes including proliferation, survival, and migration, as well as …

Constitutive egress of bone marrow (BM)-resident hematopoietic stem and progenitor cells
(HSPCs) into the blood is a well-established phenomenon, but the ultimate fate and …

Lipid mediators influence immunity in myriad ways. For example, circulating sphingosine-1-
phosphate (S1P) is a key regulator of lymphocyte egress,. Although the majority of plasma …

Abstract Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that
transmits signals through a family of G-protein-coupled receptors to control cellular …