Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural
roles in cellular membranes, some metabolites, including ceramide, sphingosine, and …

Sphingolipids are important components of eukaryotic cells, many of which function as
bioactive signaling molecules. Of these, ceramide is a central metabolite and plays key roles …

HDL is a major atheroprotective factor, but the mechanisms underlying this effect are still
obscure. HDL binding to scavenger receptor-BI has been shown to activate eNOS, although …

▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …

Rationale: Physical exercise provides benefits for various organ systems, and some of
systemic effects of exercise are mediated through modulation of muscle-derived secreted …

The mammalian heart is crafted from a few progenitor cells that are subject to rapidly
changing sets of instructions from their environment and from within. These instructions …

Cardiovascular diseases (CVDs) are the leading cause of death and illness in Europe and
worldwide, responsible for a staggering 47% of deaths in Europe. Over the past few years …

Activation of cells by receptor-and nonreceptor-mediated stimuli not only requires a change
in the activity of signaling proteins but also requires a reorganization of the topology of the …

The two lysophospholipids (LPs) lysophosphatidic acid and sphingosine 1-phosphate (S1P)
regulate diverse biological processes. Over the past decade, it has become clear that …

The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in
the regulation of cardiovascular and renal physiology containing two distinct domains …