Approaching coronavirus disease 2019: Mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2
Abstract On March 11, 2020, the World Health Organization (WHO) declared the severe
acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) a global pandemic. As …
acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) a global pandemic. As …
The nitric oxide pathway in pulmonary arterial hypertension: pathomechanism, biomarkers and drug targets
Z Lázár, M Meacute; száros… - Current Medicinal …, 2020 - benthamdirect.com
The altered Nitric Oxide (NO) pathway in the pulmonary endothelium leads to increased
vascular smooth muscle tone and vascular remodelling, and thus contributes to the …
vascular smooth muscle tone and vascular remodelling, and thus contributes to the …
The progression of pulmonary arterial hypertension induced by monocrotaline is characterized by lung nitrosative and oxidative stress, and impaired pulmonary artery …
A Zimmer, RB Teixeira, RL Constantin… - European journal of …, 2021 - Elsevier
The time-course of pulmonary arterial hypertension in the monocrotaline (MCT) model was
investigated. Male rats were divided into two groups: MCT (received a 60 mg/kg ip injection) …
investigated. Male rats were divided into two groups: MCT (received a 60 mg/kg ip injection) …
ROCK inhibition as potential target for treatment of pulmonary hypertension
TL Montagnoli, JS da Silva, SZ Sudo, AD Santos… - Cells, 2021 - mdpi.com
Pulmonary hypertension (PH) is a cardiovascular disease caused by extensive vascular
remodeling in the lungs, which ultimately leads to death in consequence of right ventricle …
remodeling in the lungs, which ultimately leads to death in consequence of right ventricle …
MiRNAs, lncRNAs, and circular RNAs as mediators in hypertension-related vascular smooth muscle cell dysfunction
JR Zhang, HJ Sun - Hypertension Research, 2021 - nature.com
Hypertension is a multifactorial disorder that involves complex genetic and environmental
factors. Vascular smooth muscle cells (VSMCs) are important components of blood vessels …
factors. Vascular smooth muscle cells (VSMCs) are important components of blood vessels …
AMPK and the challenge of treating hypoxic pulmonary hypertension
K Flores, P Siques, J Brito, SM Arribas - International Journal of Molecular …, 2022 - mdpi.com
Hypoxic pulmonary hypertension (HPH) is characterized by sustained elevation of
pulmonary artery pressure produced by vasoconstriction and hyperproliferative remodeling …
pulmonary artery pressure produced by vasoconstriction and hyperproliferative remodeling …
[HTML][HTML] Drug-drug interactions in the management of patients with pulmonary arterial hypertension
S Wu, HB Hoang, JZ Yang, DG Papamatheakis… - Chest, 2022 - Elsevier
The management of pulmonary arterial hypertension (PAH) has become more complex in
recent years because of increased pharmacotherapy options and longer patient survival …
recent years because of increased pharmacotherapy options and longer patient survival …
Epigenetic mechanisms as emerging therapeutic targets and microfluidic chips application in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a disease that progress over time and is defined
as an increase in pulmonary arterial pressure and pulmonary vascular resistance that …
as an increase in pulmonary arterial pressure and pulmonary vascular resistance that …
TRIM32 inhibits the proliferation and migration of pulmonary artery smooth muscle cells through the inactivation of PI3K/Akt pathway in pulmonary arterial …
Z Hu, Q Song, H Ma, Y Guo, T Zhang, H Xie… - Journal of Bioenergetics …, 2021 - Springer
Pulmonary arterial hypertension (PAH) is a progressive and fetal cardiovascular disease.
Tripartite motif 32 (TRIM32) is a member of TRIM family that has been found to be involved …
Tripartite motif 32 (TRIM32) is a member of TRIM family that has been found to be involved …
Cardiovascular disease complicating COVID-19 in the elderly
C Dayaramani, J De Leon, AB Reiss - Medicina, 2021 - mdpi.com
SARS-CoV-2, a single-stranded RNA coronavirus, causes an illness known as coronavirus
disease 2019 (COVID-19). The highly transmissible virus gains entry into human cells …
disease 2019 (COVID-19). The highly transmissible virus gains entry into human cells …