Addiction is a chronic, relapsing disorder. The progression to pathological drug-seeking is
thought to be driven by maladaptive learning processes which store and maintain …

Secondary injury following acute brain insults significantly contributes to poorer neurological
outcome. The spontaneous, recurrent occurrence of spreading depolarization events (SD) …

Spreading depolarization (SD) occurs alongside brain injuries and it can lead to neuronal
damage. Therefore, pharmacological modulation of SD can constitute a therapeutic …

Migraine is a common headache disorder characterized by often-severe headaches that
may be preceded or accompanied by a variety of visual symptoms. Although a typical …

Background Spreading depression (SD) is the electrophysiological substrate of migraine
aura and a potential trigger for headache. Since its discovery by Leão in 1944, SD has …

Cortical spreading depression (CSD) is a phenomenon implicated in migraine with aura and
associated with other neurological disorders (eg stroke, brain trauma). Current evidence …

Spreading depolarization (SD) is a wave of mass neuronal and glial depolarization that
propagates across the cerebral cortex and has been implicated in the pathophysiology of …

The transient receptor potential ankyrin type-1 (TRPA1) channels have been proposed as a
potential target for migraine therapy. Yet the role of cortical TRPA1 channels in migraine …

Objective Based on the capacity of the blood-resident enzyme glutamate oxaloacetate
transaminase (GOT) to metabolize blood glutamate, our aim was to study the association of …

Background Cortical spreading depression (CSD) is a transient propagating excitation of
synaptic activity followed by depression, which is implicated in migraine with aura and is …